Francis W Ruscetti

Francis W. Ruscetti, PhD has had a lifelong love affair with scientific discovery and participated in several seminal discoveries. In 1975, while a fellow at University of Pittsburgh, he discovered Interleukin-5. In 1978 at National Cancer Institute (NCI), Dr. Ruscetti's team discovered interleukin 2 (T-Cell Growth factor), for which they won a team award from the Society for Immunotherapy of Cancer. In 1980, the team he directed at the NCI isolated the first known disease-causing human retrovirus, HTLV-1, opening the field of human retrovirology, which would rise to critical importance during the HIV-AIDS epidemic. During the 1980s, his team identified IL-15, an additional immune response regulator. In hematology, his team demonstrated that human cord blood cells proliferate continuously in vitro and TGF Beta functions as a bidirectional regulator of the hematopoietic stem cell. These discoveries have all been the basis for the development of useful therapeutics.

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